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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 101

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Dimethylethylamine0.670.1 Isotonic saline solutionGuinea pigFull Thickness SkinNot Given Flow-throughHanks Balanced Salt Solution Not Given48482Gas Chromatography

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
          9 0.00268

NOTES

mean bw 640g. 6 flow-through cells were run.They tested for both DMEA and it's metabolite DMEAO in the receptor fluid. No DMEAO was found.

REFERENCE

Skin Absorption Of The Industrial Catalyst Dimethylethylamine In Vitro In Guinea Pig And Human Skin, And Of Gaseous Dimethylamine In Human Volunteers (1997) J. Pharm. Biomed. Anal., 70 :309-313