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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 102

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Dimethylethylamine0.670.1 WaterHumandermatomed to 0.25mmNot Given Flow-throughHanks Balanced Salt Solution Not Given  2Gas Chromatography

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
          26 0.0046 

NOTES

The curve shape did not allow lag time calculation. 6 flow-through cells were run.They tested for both DMEA and it's metabolite DMEAO in the receptor fluid. No DMEAO was found

REFERENCE

Skin Absorption Of The Industrial Catalyst Dimethylethylamine In Vitro In Guinea Pig And Human Skin, And Of Gaseous Dimethylamine In Human Volunteers (1997) J. Pharm. Biomed. Anal., 70 :309-313