EDETOX logo

IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 104

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

Dimethylethylamine

0.67

0.1

isotonic saline solution

Human

dermatomed to 0.25mm

Not Given

Flow-through

Hanks Balanced Salt Solution

Not Given

Gas Chromatography

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
										16		0.002	6	1

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

0.002

NOTES

6 flow-through cells were run.They tested for both DMEA and it's metabolite DMEAO in the receptor fluid. No DMEAO was found

REFERENCE

Skin Absorption Of The Industrial Catalyst Dimethylethylamine In Vitro In Guinea Pig And Human Skin, And Of Gaseous Dimethylamine In Human Volunteers (1997) J. Pharm. Biomed. Anal., 70 :309-313