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In Vitro Study No: 1056

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Anthracene0.1180.030.002AcetoneMonkeyFull Thickness SkinAbdomen1.77StaticSaline, 4% BSA & gentamycin32Skin48482HPLC

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
              13.13

NOTES

The concentration applied was given as 11.2nmol/cm2. I have converted this to mg for the database. They also gave the Kp as 3.44E-3 cm/h, but I have not included this until I check how the Kp was calculated. More than one cell was run for each compound but the actual numbers were not given.

REFERENCE

Prediction Of Percutaneous Absorption From Physicochemical Data: A Model Based On Data Of In Vitro Experiments (42) Ann. Occup. Hyg., 4 :267-276