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IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 1082

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

Benzoic Acid

1.5

Water

Human

Full Thickness Skin

Abdomen

Static

PBS

Receptor Fluid

HPLC

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
												0.025	3

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

0.025

NOTES

The concentrations of chemicals applied were not given. Lots of detail was given on the HPLC conditions. Though this has not been entered into the database. Full-thickness female abdominal skin was obtained from cosmetic surgery. They gave the logKps. I have changed these back to Kp for this database.

REFERENCE

Skin Permeability Data Anomalous Results (1998) Int. J. Pharm., 170 :129-133