EDETOX logo

IN VITRO STUDIES FURTHER DETAILS


BACK TO THE MAIN MENU

back to previous page forward to next page

University of Newcastle homepage

In Vitro Study No: 1084

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Atropine 1.5 WaterHumanFull Thickness SkinAbdomen1StaticPBS37Receptor Fluid72722HPLC

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
            7.5E-053 

NOTES

The concentrations of chemicals applied were not given. Lots of detail was given on the HPLC conditions. Though this has not been entered into the database. Full-thickness female abdominal skin was obtained from cosmetic surgery. They gave the logKps. I have changed these back to Kp for this database.

REFERENCE

Skin Permeability Data Anomalous Results (1998) Int. J. Pharm., 170 :129-133