IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1094
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Dodecane
36.1
2
14.735
JP-8
Rat
Dermatomed to 0.56mm
Back
4.9
Static
6% Volpo20 in PBS
32
Skin
4
4
1
GC
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
0.51
0.363
1.4E-05
10
NOTES
Male Fischer-344 rats were used. The cell was occluded with a glass stopper.
REFERENCE
Assessment Of Skin Absorption And Penetration Of JP-8 Jet Fuel And Its Components (2000) Toxicol. Sci., 55 :247-255
