| A thin film patch formulation was used. The patch was made using a viscous solution consisting of 0.3g drug, 0.4g Peg 400 and 0.8g of HPC-H in 20g ethanol spread on a waxed paper to approximately 1mm thickness followed by drying at 40 degree C for 1 hour. The film sheet obtained was punched into a 12mm diameter patch. 2ml of buffer was added to hydrate the patch. The thin film patch was applied on the skin, and covered with a dialysis membrane. Shed snake skin of Elaphe obsoleta (black rat snake) were used. More experimental detail is available from: M. Akazawa, T. Itoh, K. Masaki, BT Nghiem et al Int. J. Pharm. 50:53-60 (1989). N was between 3 and 7 |
