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IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 1151

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

Cortisone

Not Given

Petroleum

Human

Dermatomed to 0.35mm

Abdomen

1.13

Static

Saline

Not Given

Radiolabelled (14C)

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
								17	4.9				5

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

4.9

NOTES

An integrity test was done with tritiated water. Any samples with a Kp > than 2.5 cm/h were disgarded. Results were given as +/- SEM. I have converted this to SD for this database. They did some of the experiments in static cells as state above, but they also did some of the experiments in flow-through cells (area=0.64cm2) and they don't say which were done in each

REFERENCE

Comparison of Percutaneous Absorption Of Fragrances By Humans And Monkeys (1985) Food Chem.Toxicol., 23 :111-114