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In Vitro Study No: 1161

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Cortisone Not Given PetroleumHumanDermatomed to 0.35mmAbdomen1.13StaticSaline Not Given24242Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        9.32.9   5 

NOTES

An integrity test was done with tritiated water. Any samples with a Kp > than 2.5 cm/h were disgarded. Results were given as +/- SEM. I have converted this to SD for this database. They did some of the experiments in static cells as state above, but they also did some of the experiments in flow-through cells (area=0.64cm2) and they don't say which were done in each

REFERENCE

Comparison of Percutaneous Absorption Of Fragrances By Humans And Monkeys (1985) Food Chem.Toxicol., 23 :111-114