EDETOX logo

IN VITRO STUDIES FURTHER DETAILS


BACK TO THE MAIN MENU

back to previous page forward to next page

University of Newcastle homepage

In Vitro Study No: 1166

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Cinnamyl anthranilate Not Given0.004AcetoneHumanDermatomed to 0.35mmAbdomen1.13Static6% aq. Oleth 20 Not Given24242Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        1910.7   8 

NOTES

An integrity test was done with tritiated water. Any samples with a Kp > than 2.5 cm/h were disgarded. Results were given as +/- SEM. I have converted this to SD for this database. Can't say the exact amount absorbed as they did some of the experiments in static cells as state above, but they also did some of the experiments in flow-through cells (area=0.64cm2) and they don't say which were done in each

REFERENCE

Comparison of Percutaneous Absorption Of Fragrances By Humans And Monkeys (1985) Food Chem.Toxicol., 23 :111-114