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In Vitro Study No: 1172

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Cinnamic acid Not Given0.004AcetoneHumanDermatomed to 0.35mmAbdomen1.13StaticSaline Not Given24721Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        60.827   7 

NOTES

An integrity test was done with tritiated water. Cells were occluded with parafilm. Any samples with a Kp > than 2.5 cm/h were disgarded. Results were given as +/- SEM. I have converted this to SD for this database. Can't say the exact amount absorbed as they did some of the experiments in static cells as state above, but they also did some of the experiments in flow-through cells (area=0.64cm2) and they don't say which were done in each

REFERENCE

Comparison of Percutaneous Absorption Of Fragrances By Humans And Monkeys (1985) Food Chem.Toxicol., 23 :111-114