EDETOX logo

IN VITRO STUDIES FURTHER DETAILS


BACK TO THE MAIN MENU

back to previous page forward to next page

 University of Newcastle homepage

In Vitro Study No: 1189

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Acetylsalicylic Acid100.03 AcetoneHumanDermatomed to 0.43mmAbdomen StaticpH 7.4 Buffer37Not Given48482Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        11      

NOTES

12-16 mcrg of Caffeine was added. Skin came from a single donor. N was between 3 and 5

REFERENCE

Variations In Permeability Of Human Skin Within And Between Specimens (1984) Int. J. Pharm., 18 :299-309