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In Vitro Study No: 1205

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Benzoic Acid See Notes.0.004PetrolatumRatFull Thickness SkinAbdomen1.13StaticSaline & 0.055 Thimerosal32Water Bath  2Radioolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
            0.00044131.2

NOTES

Female Osborne-Mendel Rats were used. 30mg of petrolatum was added. The concentration added was 160ng/mg

REFERENCE

Differences In Permeability Of Rat Skin Related To Sex And Body Site (1983) J. Soc. Cosmet. Chem., 34 :127-135