IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1336
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Sodium Lauryl Sulphate
7.3
0.1
0.9359
Water
Human
Isolated Epidermis
Abdomen
0.78
Static
Saline, 0.012% Penicillin & 0.01% Streptomycin.
37
Incubator
24
24
2
Radiolabelled (14C)
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
0.42
0.3847
4
NOTES
Female abdominal skin samples were obtained at autopsy.
REFERENCE
The Percutaneous Absorption Of Some Anionic Surfactants (1975) J. Soc. Cosmet. Chem., 26 :47-63
