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In Vitro Study No: 1347

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Cinnamyl anthranilate See Notes PetrolatumRatDermatomed to 0.35mmBack1.13Static1.5% Octoxynol 932Water Bath1201202Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        38.45.8   4 

NOTES

Female Osborne-Mendel Rats were used. Results were given +/- SE. I have converted this to SD for this database. 30mg of petrolatum was added

REFERENCE

Methods For In Vitro Percutaneous Absorption Studies III: Hydrophobic Compounds (1984) J. Pharm. Sci., 73 :1255-1258