IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1359
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Acetyl ethyl tetramethyl tetralin
0.2
Acetone
Rat
Full Thickness Skin
Back
1.13
Static
Saline
32
Water Bath
43
43
2
Radiolabelled (14C)
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
0.7
0.35
12
NOTES
Female Osborne-Mendel Rats were used. Results were given +/- SE. I have converted this to SD for this database.
REFERENCE
Methods For In Vitro Percutaneous Absorption Studies III: Hydrophobic Compounds (1984) J. Pharm. Sci., 73 :1255-1258
