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In Vitro Study No: 1367

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Urea 0.04 WaterMouseNot GivenDorsal Flow-throughSaline & 0.01M unlabelled urea37Not Given662Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
            0.00034 

NOTES

Hairless Mouse Skin was used. More experimental detail to be obtained from Ackermann C et al. (1985) Percutaneous Absorption of Urea Int. J. cosmet. Sci. 7 251-261

REFERENCE

Percutaneous Absorption Of Urea And Water In Vitro In Closed And Open Diffusion Cells (1988) S. African J. Sci., 84 :440-441