IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1424
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Salicylic acid
837.33
0.03
8
dimethyl isosorbide & 2-propanol
Rat
Full Thickness Skin
Not Given
3.14
Static
0.05M isotonic phosphate buffer
32
Skin
48
48
2
HPLC
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
95.8
0.8
19.75
6.63
3
3.5
NOTES
Hairless rats were used.Concentrations are approximate. Fluxes were given as nmol/cm2/h (143). I have converted these to mcrg/cm2/hr
REFERENCE
In Vivo Skin Penetration of Salicylic Compounds in Hairless Rats (2002) Eur. J. Pharm. Sci., 17 :95-104
