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In Vitro Study No: 1427

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Diethylamine salicylate837.330.038dimethyl isosorbide & 2-propanolRatFull Thickness SkinNot Given3.14Static0.05M isotonic phosphate buffer32Skin48482HPLC

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        791210.771.06 65

NOTES

Hairless rats were used.Concentrations are approximate. Fluxes were given as nmol/cm2/h (51). I have converted these to mcrg/cm2/hr

REFERENCE

In Vivo Skin Penetration of Salicylic Compounds in Hairless Rats (2002) Eur. J. Pharm. Sci., 17 :95-104