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IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 1446

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

2-Butoxyethanol

900

0.2

281.25

Nnone (Neat)

Human

Dermatomed to 0.5mm

Breast

0.64

Flow-through

Eagles MEM, sodium hydrogen carbonate and gentamycin

Receptor Fluid

Radiolabelled (14C)

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
										1008.78	923.22		4

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

1008.78

923.22

NOTES

Steady-state flux was given in nmol/cm2/h (8536) I have converted this to mcrg/cm2/h. Results were also given +/- SEM. I have converted these to SD for the purpose of this database.

REFERENCE

Effects Of Experimental Conditions On Absorption Of Glycol Ethers Through Human Skin In Vitro (2002) Int. Arch. Occup. Environ. Health, 75 :519-527