EDETOX logo

IN VITRO STUDIES FURTHER DETAILS


BACK TO THE MAIN MENU

back to previous page forward to next page

University of Newcastle homepage

In Vitro Study No: 1500

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Glycerol Trioleate0.040.010.000512EthanolMouseFull Thickness SkinMid-Dorsal0.78StaticPBS, gentamicin & BSA37Receptor Fluid24242Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        4.70.8   6 

NOTES

Hairless mouse skin was used.

REFERENCE

The In-Vitro Percutaneous Absorption of Glycerol Trioleate Through Hairless Mouse Skin (1988) J. Pharm. Pharmacol., 40 :819-821