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In Vitro Study No: 1505

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Water9980.2255.9None (Neat)MouseFull Thickness SkinDorsal0.78StaticPBS & thimersal37Receptor Fluid24241Radiolabelled (3H)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        18.23.7   4 

NOTES

Hairless mouse skin was used. The cells were occluded with parafilm

REFERENCE

The In-Vitro Percutaneous Absorption of Glycerol Trioleate Through Hairless Mouse Skin (1988) J. Pharm. Pharmacol., 40 :819-821