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In Vitro Study No: 1517

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Butyl 4-hydroxybenzoate0.1520.0955WaterGuinea pigFull Thickness SkinDorsal3.14Flow-throughsaline37Water Bath24242Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        23.7   0.007082  

NOTES

Male Guinea Pigs were used. They also looked at how the preservative action of butylparaben is affected by different vehicles

REFERENCE

Percutaneous Absorption of Butylparaben through Guinea Pig Skin In Vitro (1979) J. Pharm. Sci., 68 :596-598