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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 1571

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Parathion Not Given0.004Not GivenHumanDermatomed to 0.5mmback1Flow-throughEagles MEM-BSS & gentamicin37Water Bath96962Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        1.780.41  0.0001894 

NOTES

Human cadaver skin was used, the skin cam from 2 donors both white males. No vehicle was mentioned in the paper.

REFERENCE

Predicted Chemical Warfare Agent VX Toxicity to Uniformed Soldier using Parathion in Vitro Human Skin Exposure and Absorption (2000) Toxicol. Appl. Pharmacol., 168 :149-152