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IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 1584

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

Malathion

0.0148

0.3

0.0154

aq. Ethanol

Human

Dermatomed to 1mm

Not Given

0.8

Flow-through

PBS

Water Bath

Radiolabelled (14C)

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
				7.63	3.48			8.77	3.5	3	1.04	0.203	6	5.1

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

7.63

3.48

8.77

3.5

1.04

0.203

5.1

NOTES

Human cadaver skin was used. Flux was given as mcrg/h. I have converted this to mcrg/cm2/h. Results were given as +/- SEM. I have converted these to SD for this database. The concentration of malathion was given as 1%. I am assuming that this was v/v and I have worked out the concentration in mg/ml by extrapolation from the kp and flux results.

REFERENCE

In Vitro Percutaneous Absorption of Model Compounds Glyphosate and Malathion from Cotton Fabric into and through Human Skin (1996) Food Chem.Toxicol., 34 :731-735