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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 1585

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Glyphosate11.220.34.208WaterHumanDermatomed to 1mmNot Given0.8Flow-throughPBS37Water Bath24242Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
    0.560.32  1.420.615.154.130.000459610.48

NOTES

Human cadaver skin was used. Flux was given as mcrg/h. I have converted this to mcrg/cm2/h. Results were given as +/- SEM. I have converted these to SD for this database. The concentration of malathion was given as 1%. I am assuming that this was v/v and I have worked out the concentration in mg/ml by extrapolation from the kp and flux results.

REFERENCE

In Vitro Percutaneous Absorption of Model Compounds Glyphosate and Malathion from Cotton Fabric into and through Human Skin (1996) Food Chem.Toxicol., 34 :731-735