IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1594
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Water
Not Given
None (Neat)
Human
Dermatomed Skin
abdomen
Static
0.9% Saline
30
Not Given
2
Radiolabelled (3H)
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
0.00171
180
NOTES
Pale Caucasian male and female skin was used. The skin was frozen for various periods. The tritiated water was added at 4mcrCi
REFERENCE
Effect of Freezing on Human Skin Permeability (1984) J. Pharm. Pharmacol., 36 :261-262
