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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 1601

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Etorphine0.2182.80.954HCl & isotonic TRIS bufferMouseFull Thickness SkinAbdominal and Dorsal0.64Staticisotonic TRIS buffer37Water Bath24242Radiolabelled (3H)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
            0.003563.7

NOTES

Hairless Mice (SKH-hr-1) were used.

REFERENCE

Etorphine is an Opiate Analgesic Physicochemically Suited to Transdermal Delivery (1992) Pharmaceut. Res., 9 :963-965