EDETOX logo

IN VITRO STUDIES FURTHER DETAILS


BACK TO THE MAIN MENU

back to previous page forward to next page

 University of Newcastle homepage

In Vitro Study No: 1602

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Etorphine0.2182.80.954HCl & isotonic TRIS bufferHumanFull Thickness SkinAbdominal0.64Staticisotonic TRIS buffer37Water Bath24242Radiolabelled (3H)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
            0.003663.1

NOTES

Human cadaver skin was used.

REFERENCE

Etorphine is an Opiate Analgesic Physicochemically Suited to Transdermal Delivery (1992) Pharmaceut. Res., 9 :963-965