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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 1686

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Parathion    Pigdermatomed to 0.5mmdorsal0.32Flow-throughKrebs-Ringer bicarbonate buffer, glucose   02Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
               

NOTES

weanling female yorkshire pigs were used.

REFERENCE

Effect of Humidity and Occlusion on the Percutaneous Absorption of Parathion In Vitro (1993) Pharmaceut. Res., 10 :152-155