IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1690
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Aniline
1020
0.32
504
undiluted
Human
Full Thickness Skin
abdomen, thigh, upper arm
0.64
Static
0.9%NaCl
34
Skin
8
8
1
GCMS
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
0.45
0.12
725.2
213.5
2.8
NOTES
REFERENCE
Percutaneous absorption of aromatic amines – A contribution for human health risk assessment (2008) Food Chem.Toxicol., 46 :1960-1968
