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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 1692

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Aniline300.3215salineHumanFull Thickness SkinAbdomen,thigh,upper arm0.64Static0.9%Nacl34Skin24241GCMS

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        19.80.83218.34.6  1.2

NOTES

 

REFERENCE

Percutaneous absorption of aromatic amines – A contribution for human health risk assessment (2008) Food Chem.Toxicol., 46 :1960-1968