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IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 1697

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

Propoxur

2.75

0.032

0.137

60%(v/v)ethanol:water

Human

Full Thickness Skin

abdomen

0.64

Flow-through

0.9%NaCl plus 3% BSA

Skin

Scintillation counting

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
88	4.3			23.6	3.9	74.7				4.7	0.4			5.3

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

4.3

23.6

3.9

74.7

4.7

0.4

5.3

NOTES

Viable skin includes stratum corneum. Lag times are apparent.

REFERENCE

Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies (2006) Int. Arch. Occup. Environ. Health, 79 :405-413