IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1698
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Propoxur
2.75
0.032
0.137
60%(v/v) ethanol:water
Human
Isolated Epidermis
abdomen
0.64
Flow-through
0.9%NaCl plus 3%BSA
32
Skin
24
24
1
Scintillation counting
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
91
0.8
6.7
0.8
89.2
82.5
1.6
13.1
1.5
4.9
NOTES
Viable skin includes stratum corneum. Lag times are apparent.
REFERENCE
Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies (2006) Int. Arch. Occup. Environ. Health, 79 :405-413
