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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 170

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
2-Phenoxyethanol730.011.14MethanolRatDermatomed to 0.244mmDorsal0.64Flow-throughMEM & penicilllin/streptomycin + CO237Receptor Fluid24242Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
51 2.90.31.60.447.5 433.7  0.00176460

NOTES

Only 51% of the applied dose was accounted for 24h post dose. The loss is expected to be due to evaporation.

REFERENCE

Percutaneous Penetration Of 2-Phenoxyethanol Through Rat And Human Skin (1997) Food Chem.Toxicol., 35 :1009-1016