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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 1700

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Propoxur2.610.0320.1310%(v/v) ethanol:waterHumanIsolated EpidermisBreast0.64Flow-through0.9% NaCl plus 3% BSA32Skin24241Scintillation counting

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
92.33.7  4.4189.3 84.9511.50.8  3.4

NOTES

Viable skin includes stratum corneum. Lag times are apparent.

REFERENCE

Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies (2006) Int. Arch. Occup. Environ. Health, 79 :405-413