EDETOX logo

IN VITRO STUDIES FURTHER DETAILS


BACK TO THE MAIN MENU

back to previous page forward to next page

University of Newcastle homepage

In Vitro Study No: 1702

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Pirimicarb0.0480.60.0130.9% NaCl in water plus 2%ethanolHumanFull Thickness SkinBreast and abdomen2.12Static0.9% NaCl32Skin2401HPLC

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        28.21.80.130.01  6

NOTES

Exposure time in metholds is 30 h.

REFERENCE

Percutaneous penetration through slightly damaged skin (2005) Arch. Dermatol. Res., 296 :560-567