IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1704
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Paclobutrazol
0.059
0.6
0.017
0.9% NaCl in water plus 2% ethanol
Human
Full Thickness Skin
Breast and abdomen
2.12
Static
0.9% NaCl
32
Skin
24
24
1
HPLC
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
9.5
2.1
0.14
0.02
17.1
NOTES
exposure time in method is 30h.
REFERENCE
Percutaneous penetration through slightly damaged skin (2005) Arch. Dermatol. Res., 296 :560-567
