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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 1708

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
o-toluidine10080.32504undilutedHumanFull Thickness SkinAbdomen and thigh0.64Static0.9% NaCl34Skin441GCMS

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        0.040.0166.618.9  1.4

NOTES

 

REFERENCE

Enhancement of percutaneous penetration of aniline and o-toluidine in vitro using skin barrier creams (2008) Toxicol. Vitro, 22 :812-818