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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 1709

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
MDA50.320.25Saline/EtOH 1:1HumanFull Thickness SkinAbdomen, thigh, upper arm0.64Static0.9% NaCl34Skin24241GCMS

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        14.63.734.511  10.9

NOTES

Very few data points. No absorption detected from 0.03 mg/ml.

REFERENCE

Percutaneous absorption of aromatic amines – A contribution for human health risk assessment (2008) Food Chem.Toxicol., 46 :1960-1968