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In Vitro Study No: 171

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
2-Phenoxyethanol21.50.010.272MethanolRatDermatomed to 0.244mmDorsal0.79Static50% aq. Ethanol37Receptor Fluid24241Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
102.6 1.20.10.71.195.9 9418.4147.8425.130.0073560

NOTES

Occluded with parafilm. Volume added was given as 1556 nmol or 0.81mCi. Sp Activity was 3.74mCi/mg. The rats were Male Wistar Rats and hair was removed from the dorsal skin with clippers. The results were given as +/- SEM. I have converted this to SD for this database.

REFERENCE

Percutaneous Penetration Of 2-Phenoxyethanol Through Rat And Human Skin (1997) Food Chem.Toxicol., 35 :1009-1016