EDETOX logo

IN VITRO STUDIES FURTHER DETAILS


BACK TO THE MAIN MENU

back to previous page forward to next page

University of Newcastle homepage

In Vitro Study No: 1712

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
2-Naphthylamine0.030.320.015PBS/EtHO 95:5HumanFull Thickness SkinAbdomen, thigh, upper arm0.64Static0.9% NaCl34Skin24241GCMS

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        54.130.510.05  1.2

NOTES

 

REFERENCE

Penetration of β-naphthylamine and o-toluidine through human skin in vitro (2006) Arch. Toxicol., 80 :644-646