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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 1716

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
2-Butoxyethanol4520.12857.9waterHumanFull Thickness SkinBreast0.64Flow-through0.9% NaCl32Skin4241Scintillation counting

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
650.9  0.60.12 1.40.2703114  1.3

NOTES

Viable skin includes stratum corneum. Lag times are apparent.

REFERENCE

Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies (2006) Int. Arch. Occup. Environ. Health, 79 :405-413