IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1721
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Trimethylamine
500
0.02
31.25
water
Human
Full Thickness Skin
abdomen
0.32
Flow-through
0.9% NaCl
32
Skin
24
24
1
LSC
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
6
1.6
92.7
31.9
0.00019
6E-05
NOTES
REFERENCE
The passage of trimethylamine across rat and human skin (2004) Food Chem.Toxicol., 42 :1619-1628
