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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 1722

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Trimethylamine500.023.125waterHumanFull Thickness Skinabdomen0.32Flow-through0.9% NaCl32Skin24241LDC

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        5.62.19.213.060.000177E-05 

NOTES

 

REFERENCE

The passage of trimethylamine across rat and human skin (2004) Food Chem.Toxicol., 42 :1619-1628