IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1726
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Dipropylene glycol methyl ether
476
0.658
95.1
50% in water
Human
Full Thickness Skin
abdomen
3.29
Static
0.9% NaCl
32
Receptor Fluid
8
8
1
GC
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
0.27
42.4
7.9
8E-05
1.5E-05
2.17
NOTES
Assume ideal mixing with no reduction in volume.
REFERENCE
Percutaneous absorption of 5 glycol ethers through human skin in vitro (2004) Toxicol. Vitro, 18 :665-671
