IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1729
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
n-Propoxyethanol
457
0.658
91.3
50% in water
Human
Full Thickness Skin
abdomen
3.29
Static
0.9%NaCl
32
Receptor Fluid
8
8
1
GC
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
3.3
565
94
0.00103
0.00017
1.9
NOTES
Assume ideal mixing whith no reduction in volume.
REFERENCE
Percutaneous absorption of 5 glycol ethers through human skin in vitro (2004) Toxicol. Vitro, 18 :665-671
