IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 1731
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
2-Isopropoxyethanol
451.5
0.658
90.3
50% in water
Human
Full Thickness Skin
abdomen
3.29
Static
0.9% NaCl
32
Receptor Fluid
8
8
1
GC
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
1.55
246
22
0.00044
3.8E-05
1.97
NOTES
Assume ideal mixing with no reduction in volume
REFERENCE
Percutaneous absorption of 5 glycol ethers through human skin in vitro (2004) Toxicol. Vitro, 18 :665-671
