IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 181
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Cortexolone
0.00346
2.5
Water
Human
Isolated Epidermis
Not Given
Static
Aq. Penicillin/streptomycin
26
Not Given
2
Radiolabelled
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
0.000259
7.5E-05
NOTES
100 micro curies of the steroid was used. Further experimental method can be derived from other papers. J. Invest. Derm. 45:334 (1966), J. Invest. Derm 48:79 (1967) J. Invest Derm. 49:5S2 (1967)
REFERENCE
Percutaneous Absorption Of Steroids (1969) J. Investig. Dermatol., 52 :63-70
